Start Off With Rituals
Key takeaway:
Rituals grant omens which may change which modifiers will be added to an item when a specific orb is used.
Use these to minimize monster strength but maximize the loot.
Why is this useful?
omen_of_sinistral_alchemy will add result in the maximum number of prefixes when used with a orb of alchemy
Why is this important?
The prefixes on Waystones are bonuses you receive e.g. increased rarity of items found
That way you maximize the amount of bonuses while limiting the amount of suffixes or rather deficits on a Waystone.
The same is true for Omen of Sinistral Exaltation and Omen Of Sinistral Coronation